PRKD2

Across TCGA cell cohorts, PRKD2 mutation is significantly associated with the RNA expression of many other genes, with 85 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRKD2-associated genes across cancer lineages are SLC32A1, MOS, and SMIM9. Each is linked with PRKD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKD2-to-partner and partner-to-PRKD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by PRKD2-low versus PRKD2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKD2→partner) and Y-score (partner→PRKD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC32A1 →	+0.539	+2.638	<.001	.009	3	2
BLOOD_Myeloma	MOS →	+0.040	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SMIM9 →	+0.020	+4.807	<.001	.006	3	1
BLOOD_Lymphoma	LUZP4 →	+0.056	+4.350	.004	.005	3	1
BLOOD_Lymphoma	BMP15 →	+0.021	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	TEX50 →	+0.042	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

SLC32A1 by PRKD2 expression — BLOOD_Leukemia

Explore this box plot interactively →