Across TCGA pan-cancer cohorts, PRKD1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PRKD1 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PRKD1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRKD1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where PRKD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	III,IV	0.437	1.000	.002	41	view →
CCRCC	OS	Median	All	0.937	0.750	.004	27	view →
LUAD	DFS	Median	II,III,IV	0.898	0.232	.003	19	view →
HNSC	OS	Quartile	IV	0.722	0.977	.001	7	view →
PDAC	DFS	Median	III,IV	0.203	0.507	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: PRKD1 tumor-vs-normal RNA expression · all PRKD1 data types