Across TCGA patient cohorts, PRKD1 mutation is significantly associated with the RNA expression of many other genes, with 5,048 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKD1-associated genes across cancer lineages are CHAC2, SEH1L, and GSR. Each is linked with PRKD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PRKD1-to-partner and partner-to-PRKD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKD1→partner) and Y-score (partner→PRKD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAC2 →	+0.492	+2.928	.001	<.001	3	5
LUAD	SEH1L →	+0.410	+2.735	.006	.003	3	4
UCEC	GSR →	+0.800	+1.857	<.001	<.001	3	4
UCEC	ACBD5 →	+0.429	+1.637	.002	.001	3	4
HNSC	HBQ1 →	+0.628	+2.475	.001	.004	2	4
HNSC	RPL6 →	+0.462	+2.700	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,048 associations by consensus.

Exploration

PRKD1 survival (RNA) · tumor vs normal (RNA) · all PRKD1 data types