Across TCGA cell cohorts, PRKD1 mutation is significantly associated with the RNA expression of many other genes, with 1,415 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKD1-associated genes across cancer lineages are OTX1, CNNM2, and ZBTB48. Each is linked with PRKD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKD1-to-partner and partner-to-PRKD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKD1→partner) and Y-score (partner→PRKD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OTX1 →	+0.765	+2.829	<.001	<.001	3	2
LARGE_INTESTINE	CNNM2 →	+0.508	+2.743	.008	.001	3	2
LARGE_INTESTINE	ZBTB48 →	+0.458	+3.301	.006	.003	3	2
OESOPHAGUS	LGALS13 →	+0.073	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	CSH1 →	+0.044	+4.343	<.001	.002	3	1
LUNG_NSCLC_LUAD	TRIM43B →	+0.025	+3.857	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,415 associations by consensus.

Exploration

PRKD1 survival (RNA) · tumor vs normal (RNA) · all PRKD1 data types