PRKCZ

Across TCGA pan-cancer cohorts, PRKCZ mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PRKCZ data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PRKCZ mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PRKCZ expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where PRKCZ mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.904	0.333	.031	14	view →
HNSC	DFS	Median	All	0.856	0.685	.018	11	view →
LUAD	OS	Tertile	III,IV	0.307	0.879	.008	11	view →
PDAC	OS	Median	All	0.397	0.578	.025	9	view →
CCRCC	DFS	Tertile	All	1.000	0.675	.023	2	view →
LSCC	OS	Median	All	1.000	0.800	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PRKCZ–UCEC (OS)

Open the UCEC breakdown →