PRKCZ

Across TCGA patient cohorts, PRKCZ mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCZ-associated genes across cancer lineages are PI3K-p110-a, Cyclin-E1, and JNK_pT183_Y185. Each is linked with PRKCZ in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKCZ-to-partner and partner-to-PRKCZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p110-a grouped by PRKCZ-low versus PRKCZ-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCZ→partner) and Y-score (partner→PRKCZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PI3K-p110-a →	+0.231	+2.824	.013	.034	3	2
COAD	Cyclin-E1 →	+0.309	+2.815	.024	.036	3	2
UCEC	JNK_pT183_Y185 →	-0.148	-1.765	.007	.013	3	2
UCEC	MEK1 →	+0.430	+3.169	<.001	<.001	3	2
UCEC	Notch1 →	+0.128	+2.235	.005	.005	3	2
UCEC	Rad50 →	-0.221	-1.652	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

PI3K-p110-a by PRKCZ expression — SKCM

Explore this box plot interactively →