PRKCZ-AS1

Across TCGA pan-cancer cohorts, PRKCZ-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PRKCZ-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PRKCZ-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRKCZ-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

KIRC, ACC, and KICH are the cancer types where PRKCZ-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.384	0.621	<.001	80	view →
ACC	DFS	Median	All	0.277	0.592	<.001	72	view →
KICH	OS	Median	III,IV	0.766	1.000	.006	53	view →
HNSC	OS	Median	II,III,IV	0.743	0.597	.002	51	view →
BLCA	OS	Tertile	II,III,IV	0.821	0.646	.002	36	view →
BRCA	OS	Median	All	0.945	0.902	.003	22	view →
COAD	OS	Tertile	III,IV	0.672	0.914	.009	22	view →
PRAD	DFS	Median	All	0.833	0.927	<.001	22	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	21	view →
SKCM	DFS	Median	II,III,IV	0.273	0.178	.013	20	view →
LIHC	DFS	Quartile	III,IV	0.150	0.490	.001	19	view →
THYM	DFS	Quartile	All	0.965	0.592	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PRKCZ-AS1–KIRC (DFS)

Open the KIRC breakdown →