PRKCSH

Across TCGA patient cohorts, PRKCSH mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCSH-associated genes across cancer lineages are eIF4E, JNK2, and Annexin-1. Each is linked with PRKCSH in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKCSH-to-partner and partner-to-PRKCSH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PRKCSH-low versus PRKCSH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCSH→partner) and Y-score (partner→PRKCSH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.229	+3.183	.010	.009	3	2
UCEC	JNK2 →	+0.334	+2.331	<.001	.019	3	2
UCEC	Annexin-1 →	+0.497	+3.479	.026	.002	3	2
UCEC	TFRC →	+0.522	+1.700	.020	.044	3	2
UCEC	ATM →	-0.550	-2.222	.004	.011	3	2
UCEC	Caspase-7-cleavedD198 →	+0.817	+2.479	.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eIF4E by PRKCSH expression — UCEC

Explore this box plot interactively →