PRKCSH

Across TCGA cell cohorts, PRKCSH mutation is significantly associated with the RNA expression of many other genes, with 225 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKCSH-associated genes across cancer lineages are EFCAB9, IQCF5, and MED26. Each is linked with PRKCSH in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKCSH-to-partner and partner-to-PRKCSH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EFCAB9 grouped by PRKCSH-low versus PRKCSH-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCSH→partner) and Y-score (partner→PRKCSH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EFCAB9 →	+0.103	+3.584	.002	.008	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1
LARGE_INTESTINE	MED26 →	+0.325	+3.067	.003	.009	3	1
LARGE_INTESTINE	KLF1 →	+0.103	+3.234	<.001	.005	3	1
LARGE_INTESTINE	NDUFS7 →	+0.642	+3.212	.003	.006	3	1
LARGE_INTESTINE	IL1R2 →	+2.942	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 225 associations by consensus.

EFCAB9 by PRKCSH expression — OESOPHAGUS

Explore this box plot interactively →