PRKCI

Across TCGA patient cohorts, PRKCI mutation is significantly associated with the RNA expression of many other genes, with 2,627 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCI-associated genes across cancer lineages are C1orf174, NPM1P9, and H2AC14. Each is linked with PRKCI in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKCI-to-partner and partner-to-PRKCI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf174 grouped by PRKCI-low versus PRKCI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCI→partner) and Y-score (partner→PRKCI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C1orf174 →	+0.453	+2.534	<.001	<.001	3	3
SKCM	NPM1P9 →	+0.538	+3.516	<.001	.002	3	3
COAD	H2AC14 →	+1.465	+3.249	<.001	.008	3	3
COAD	BCAS2 →	+0.518	+3.335	.003	.005	3	3
UCEC	RPA2 →	+0.551	+3.000	<.001	<.001	3	3
UCEC	PSMC3IP →	+0.786	+3.010	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,627 associations by consensus.

C1orf174 by PRKCI expression — UCEC

Explore this box plot interactively →