PRKCI

Across TCGA cell cohorts, PRKCI mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRKCI-associated genes across cancer lineages are NPVF, OCM2, and SEPTIN14. Each is linked with PRKCI in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKCI-to-partner and partner-to-PRKCI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by PRKCI-low versus PRKCI-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCI→partner) and Y-score (partner→PRKCI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NPVF →	+0.020	+5.000	<.001	.005	3	1
KIDNEY	OCM2 →	+0.083	+5.000	<.001	.005	3	1
KIDNEY	SEPTIN14 →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	GLYATL3 →	+0.043	+5.000	<.001	.005	3	1
KIDNEY	KLF18 →	+0.006	+5.000	<.001	.005	3	1
SKIN	OR5B3 →	+0.044	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

NPVF by PRKCI expression — KIDNEY

Explore this box plot interactively →