PRKCH

Across TCGA pan-cancer cohorts, PRKCH mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PRKCH data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PRKCH mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PRKCH expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where PRKCH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.940	0.699	.002	49	view →
PDAC	OS	Median	II,III,IV	0.756	0.940	.017	7	view →
HNSC	DFS	Median	IV	0.923	0.694	.011	5	view →
LUAD	OS	Median	II,III,IV	0.863	0.999	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PRKCH–CCRCC (OS)

Open the CCRCC breakdown →