PRKCH

Across TCGA patient cohorts, PRKCH mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCH-associated genes across cancer lineages are p38-MAPK_pT180_Y182, S6_pS240_S244, and 4E-BP1. Each is linked with PRKCH in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKCH-to-partner and partner-to-PRKCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by PRKCH-low versus PRKCH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCH→partner) and Y-score (partner→PRKCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.381	-1.649	.016	.011	3	2
UCEC	S6_pS240_S244 →	+0.332	+1.362	.020	.037	3	2
UCEC	4E-BP1 →	+0.204	+2.029	.033	.017	3	2
UCEC	Cyclin-E2 →	+0.152	+1.710	.010	.025	3	2
UCEC	Dvl3 →	+0.140	+1.662	.030	.011	3	2
UCEC	eIF4E →	+0.158	+2.000	.034	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

p38-MAPK_pT180_Y182 by PRKCH expression — UCEC

Explore this box plot interactively →