PRKCH

Across TCGA cell cohorts, PRKCH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,891 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRKCH-associated GO terms across cancer lineages are Phospholipase C/protein kinase C signal transduction, Maintenance of cell polarity, and Rho protein signal transduction. Each is linked with PRKCH in more than 9 cancer types. Because this analysis shows association rather than direction, both PRKCH-to-partner and partner-to-PRKCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phospholipase C/protein kinase C signal transduction grouped by PRKCH-low versus PRKCH-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCH→partner) and Y-score (partner→PRKCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Phospholipase C/protein kinase C signal transduction →	+1.228	+2.705	.002	.001	3	10
BREAST	Maintenance of cell polarity →	+0.159	+1.589	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Rho protein signal transduction →	+0.085	+1.356	.004	.001	3	9
URINARY_TRACT	Positive regulation of synapse structural plasticity →	-1.611	-2.127	<.001	<.001	3	8
URINARY_TRACT	Regulation of glial cell proliferation →	+0.208	+2.657	<.001	<.001	3	8
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.044	+1.569	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,891 associations by consensus.

Phospholipase C/protein kinase C signal transduction by PRKCH expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →