PRKCH

Across TCGA cell cohorts, PRKCH mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKCH-associated genes across cancer lineages are PRAMEF25, MAGEB4, and GFRA4. Each is linked with PRKCH in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKCH-to-partner and partner-to-PRKCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF25 grouped by PRKCH-low versus PRKCH-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCH→partner) and Y-score (partner→PRKCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PRAMEF25 →	+0.013	+5.087	<.001	.004	3	1
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	GFRA4 →	+0.019	+3.345	.001	.007	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.660	+3.772	<.001	.003	3	1
LARGE_INTESTINE	TKTL2 →	+0.046	+4.187	<.001	.002	3	1
LARGE_INTESTINE	BPY2 →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PRAMEF25 by PRKCH expression — URINARY_TRACT

Explore this box plot interactively →