PRKCD

Across TCGA patient cohorts, PRKCD mutation is significantly associated with the RNA expression of many other genes, with 1,607 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCD-associated genes across cancer lineages are GALNT6, RNA5SP147, and LIN7C. Each is linked with PRKCD in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKCD-to-partner and partner-to-PRKCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALNT6 grouped by PRKCD-low versus PRKCD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCD→partner) and Y-score (partner→PRKCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GALNT6 →	-0.809	-3.657	<.001	.001	3	3
BRCA	RNA5SP147 →	+0.260	+5.324	<.001	.003	3	2
UCEC	LIN7C →	+0.521	+2.593	.003	.006	3	2
UCEC	NOCT →	+0.590	+2.595	<.001	.005	3	2
COAD	YAF2 →	+0.399	+3.486	.009	.002	3	2
UCEC	C18orf25 →	+0.457	+3.595	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,607 associations by consensus.

GALNT6 by PRKCD expression — UCEC

Explore this box plot interactively →