PRKCD

Across TCGA patient cohorts, PRKCD mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCD-associated genes across cancer lineages are C-Raf, DJ-1, and A-Raf_pS299. Each is linked with PRKCD in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKCD-to-partner and partner-to-PRKCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by PRKCD-low versus PRKCD-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCD→partner) and Y-score (partner→PRKCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.197	+3.008	.009	.019	3	3
COAD	DJ-1 →	+0.208	+3.008	.030	.019	3	2
UCEC	A-Raf_pS299 →	-0.114	-2.321	.021	.034	3	2
UCEC	Annexin-1 →	+0.656	+3.341	.002	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.749	+2.321	.002	.033	3	2
UCEC	Caspase-8 →	-0.286	-3.295	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

C-Raf by PRKCD expression — COAD

Explore this box plot interactively →