PRKCD

Across TCGA cell cohorts, PRKCD mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKCD-associated genes across cancer lineages are FAM78A, HRH4, and ST6GAL2. Each is linked with PRKCD in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKCD-to-partner and partner-to-PRKCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM78A grouped by PRKCD-low versus PRKCD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCD→partner) and Y-score (partner→PRKCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM78A →	+0.619	+3.064	<.001	.009	3	1
LARGE_INTESTINE	HRH4 →	+0.064	+3.432	<.001	.005	3	1
LARGE_INTESTINE	ST6GAL2 →	+0.636	+2.839	.006	.004	3	1
LARGE_INTESTINE	ACER1 →	+0.089	+2.560	<.001	.009	3	1
LARGE_INTESTINE	CX3CR1 →	+0.136	+3.215	.002	.009	3	1
LARGE_INTESTINE	MNT →	+0.699	+3.064	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

FAM78A by PRKCD expression — LARGE_INTESTINE

Explore this box plot interactively →