PRKCB

Across TCGA patient cohorts, PRKCB mutation is significantly associated with the RNA expression of many other genes, with 4,257 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCB-associated genes across cancer lineages are ATP5IF1, VDAC2, and ZBTB8OS. Each is linked with PRKCB in more than 4 cancer types. Because this analysis shows association rather than direction, both PRKCB-to-partner and partner-to-PRKCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5IF1 grouped by PRKCB-low versus PRKCB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCB→partner) and Y-score (partner→PRKCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP5IF1 →	+0.330	+1.776	.003	<.001	3	5
SKCM	VDAC2 →	+0.308	+1.565	.001	.007	3	4
SKCM	ZBTB8OS →	+0.323	+1.893	<.001	<.001	3	4
UCEC	SKA1 →	+0.543	+2.928	<.001	<.001	3	4
UCEC	POC1A →	+0.509	+4.000	.001	<.001	3	4
UCEC	CENPX →	+0.406	+2.119	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,257 associations by consensus.

ATP5IF1 by PRKCB expression — UCEC

Explore this box plot interactively →