PRKCB

Across TCGA patient cohorts, PRKCB mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCB-associated genes across cancer lineages are PAI-1, ATM, and TIGAR. Each is linked with PRKCB in more than 3 cancer types. Because this analysis shows association rather than direction, both PRKCB-to-partner and partner-to-PRKCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by PRKCB-low versus PRKCB-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCB→partner) and Y-score (partner→PRKCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PAI-1 →	+0.611	+3.468	.042	.002	3	4
UCEC	ATM →	-0.572	-2.247	<.001	.001	3	4
LUAD	TIGAR →	+0.270	+2.584	.003	.010	3	3
SKCM	N-Ras →	+0.101	+2.502	.020	.001	3	3
UCEC	FoxM1 →	+0.165	+1.289	.046	.023	3	3
UCEC	Notch1 →	+0.111	+1.498	.013	.032	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

PAI-1 by PRKCB expression — LUSC

Explore this box plot interactively →