PRKCA

Across TCGA pan-cancer cohorts, PRKCA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PRKCA data layer compared with 19 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PRKCA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRKCA expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where PRKCA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.431	0.928	<.001	60	view →
CCRCC	DFS	Tertile	III,IV	0.292	0.758	.001	30	view →
UCEC	OS	Tertile	III,IV	0.345	1.000	.010	28	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
LSCC	DFS	Median	All	0.520	0.933	.001	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PRKCA–HNSC (DFS)

Open the HNSC breakdown →