PRKAR2B

Across TCGA patient cohorts, PRKAR2B mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKAR2B-associated genes across cancer lineages are MEK1, Shc_pY317, and ERK2. Each is linked with PRKAR2B in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAR2B-to-partner and partner-to-PRKAR2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PRKAR2B-low versus PRKAR2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAR2B→partner) and Y-score (partner→PRKAR2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.422	+3.700	.004	.001	3	2
UCEC	Shc_pY317 →	-0.160	-2.415	.008	.003	3	2
UCEC	ERK2 →	+0.152	+2.999	.049	.035	3	1
UCEC	GSK-3_pS9 →	-0.346	-2.321	.033	.033	3	1
UCEC	JNK2 →	+0.185	+1.906	.020	.016	3	1
UCEC	Ku80 →	+0.240	+1.498	.011	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MEK1 by PRKAR2B expression — UCEC

Explore this box plot interactively →