PRKAR2B

Across TCGA cell cohorts, PRKAR2B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,262 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRKAR2B-associated GO terms across cancer lineages are Protein-DNA complex organization, Protein deneddylation, and Protein localization to nucleus. Each is linked with PRKAR2B in more than 11 cancer types. Because this analysis shows association rather than direction, both PRKAR2B-to-partner and partner-to-PRKAR2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-DNA complex organization grouped by PRKAR2B-low versus PRKAR2B-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAR2B→partner) and Y-score (partner→PRKAR2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Protein-DNA complex organization →	+0.057	+1.619	.007	<.001	2	12
LIVER	Protein deneddylation →	+0.102	+2.202	.003	.003	3	10
STOMACH	Protein localization to nucleus →	+0.062	+1.727	<.001	.003	3	10
SOFT_TISSUE	Nucleocytoplasmic transport →	+0.047	+1.368	<.001	<.001	3	10
BONE	Positive regulation of double-strand break repair →	+0.066	+1.225	<.001	.001	3	10
SOFT_TISSUE	Nuclear transport →	+0.047	+1.421	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,262 associations by consensus.

Protein-DNA complex organization by PRKAR2B expression — LUNG_SCLC

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