PRKAR2B

Across TCGA cell cohorts, PRKAR2B mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PRKAR2B-associated genes across cancer lineages are DNAAF6 and FAM236A. Each is linked with PRKAR2B in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAR2B-to-partner and partner-to-PRKAR2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAAF6 grouped by PRKAR2B-low versus PRKAR2B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAR2B→partner) and Y-score (partner→PRKAR2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DNAAF6 →	+0.041	+3.693	<.001	.009	3	1
OVARY	FAM236A →	+0.334	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

DNAAF6 by PRKAR2B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →