PRKAR2B

Across TCGA cell cohorts, PRKAR2B mutation is significantly associated with the mutation status of many other genes, with 2,281 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKAR2B-associated genes across cancer lineages are OTUD7A, GAK, and LILRA4. Each is linked with PRKAR2B in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKAR2B-to-partner and partner-to-PRKAR2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTUD7A grouped by PRKAR2B-low versus PRKAR2B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAR2B→partner) and Y-score (partner→PRKAR2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OTUD7A →	+3.718	+3.718	.003	.003	1	3
LUNG_NSCLC_LUAD	GAK →	+2.396	+3.342	.006	.006	1	3
LARGE_INTESTINE	LILRA4 →	+4.329	+4.329	.001	.001	1	3
LARGE_INTESTINE	DMC1 →	+3.744	+4.044	.003	.003	1	3
LARGE_INTESTINE	SPTLC2 →	+3.007	+3.584	.008	.008	1	3
LARGE_INTESTINE	MTCH2 →	+4.329	+4.329	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,281 associations by consensus.

OTUD7A by PRKAR2B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →