PRKAR2A

Across TCGA pan-cancer cohorts, PRKAR2A mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PRKAR2A’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PRKAR2A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PRKAR2A is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, HNSC, and LSCC are the cancer types where PRKAR2A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKAR2A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	−0.453	<.001	12	view →
HNSC	Male	II,III,IV	−0.611	<.001	11	view →
LSCC	Female	All	−0.719	<.001	9	view →
LUAD	Male	III,IV	−0.415	<.001	9	view →
COAD	Male	II,III,IV	−0.221	<.001	9	view →
PDAC	Female	II,III,IV	−0.512	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PRKAR2A–CCRCC

Open the CCRCC breakdown →