Across TCGA pan-cancer cohorts, PRKAR2A-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated PRKAR2A-AS1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher PRKAR2A-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PRKAR2A-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LUAD show a favorable association.

BRCA, LUAD, and KICH are the cancer types where PRKAR2A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.948	0.901	.002	88	view →
LUAD	OS	Median	All	0.756	0.584	.002	73	view →
KICH	DFS	Median	II,III,IV	0.697	1.000	.003	64	view →
UVM	DFS	Median	All	0.724	0.421	.001	61	view →
SKCM	DFS	Quartile	II,III,IV	0.383	0.149	<.001	51	view →
UCS	DFS	Median	II,III,IV	0.543	0.144	.002	48	view →
READ	OS	Tertile	III,IV	1.000	0.731	.002	43	view →
LIHC	DFS	Median	All	0.465	0.615	<.001	42	view →
KIRC	DFS	Quartile	All	0.890	0.685	.002	32	view →
MESO	DFS	Median	IV	0.201	0.482	.018	24	view →
CHOL	DFS	Median	II,III,IV	0.624	0.125	.017	18	view →
ACC	OS	Quartile	All	1.000	0.799	.004	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

Exploration

Same gene, other analysis: PRKAR2A-AS1 tumor-vs-normal RNA expression · all PRKAR2A-AS1 data types