Across TCGA patient cohorts, PRKAR1B mutation is significantly associated with the RNA expression of many other genes, with 1,703 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKAR1B-associated genes across cancer lineages are SNORA3C, RWDD1, and ZUP1. Each is linked with PRKAR1B in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKAR1B-to-partner and partner-to-PRKAR1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAR1B→partner) and Y-score (partner→PRKAR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SNORA3C →	+0.474	+4.268	.004	.008	3	3
SKCM	RWDD1 →	+0.586	+3.328	.009	.005	3	2
SKCM	ZUP1 →	+0.633	+3.353	.009	.005	3	2
UCEC	FANCB →	+0.451	+3.700	.001	.001	3	2
UCEC	RWDD4 →	+0.513	+2.169	.001	.003	3	2
UCEC	QRFP →	+0.350	+2.212	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,703 associations by consensus.

Exploration

PRKAR1B survival (RNA) · tumor vs normal (RNA) · all PRKAR1B data types