Across TCGA patient cohorts, PRKAR1B mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKAR1B-associated genes across cancer lineages are eEF2, eIF4E, and A-Raf_pS299. Each is linked with PRKAR1B in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAR1B-to-partner and partner-to-PRKAR1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAR1B→partner) and Y-score (partner→PRKAR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.397	+2.000	.004	.029	3	1
UCEC	eIF4E →	+0.197	+3.335	.017	.005	3	1
UCEC	A-Raf_pS299 →	-0.170	-3.584	<.001	.002	3	1
UCEC	ERK2 →	+0.226	+2.000	.002	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.137	-1.584	.005	.036	3	1
UCEC	GAPDH →	+0.830	+3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration

PRKAR1B survival (RNA) · tumor vs normal (RNA) · all PRKAR1B data types