Across TCGA cell cohorts, PRKAR1B mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKAR1B-associated genes across cancer lineages are OR10G3, SPANXN4, and SPATA31D1. Each is linked with PRKAR1B in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAR1B-to-partner and partner-to-PRKAR1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAR1B→partner) and Y-score (partner→PRKAR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR10G3 →	+0.047	+4.643	<.001	.004	3	1
LUNG_SCLC	SPANXN4 →	+0.202	+4.643	<.001	.004	3	1
LUNG_SCLC	SPATA31D1 →	+0.632	+4.643	<.001	.004	3	1
LUNG_SCLC	CT47A7 →	+0.017	+4.643	<.001	.004	3	1
LUNG_SCLC	TEX50 →	+0.030	+4.643	<.001	.004	3	1
LUNG_SCLC	OR1D5 →	+0.025	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Exploration

PRKAR1B survival (RNA) · tumor vs normal (RNA) · all PRKAR1B data types