Across TCGA pan-cancer cohorts, PRKAR1B-AS2 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PRKAR1B-AS2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where PRKAR1B-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types PRKAR1B-AS2 is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.
KICH, KIRC, and HNSC are the cancer types where PRKAR1B-AS2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKAR1B-AS2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.