PRKAR1B-AS1

Across TCGA pan-cancer cohorts, PRKAR1B-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PRKAR1B-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PRKAR1B-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRKAR1B-AS1 expression acts as an unfavorable survival marker, although some lineages such as THYM and SKCM show a favorable association.

KIRC, UVM, and LGG are the cancer types where PRKAR1B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.510	0.707	<.001	172	view →
UVM	OS	Quartile	All	0.473	1.000	<.001	126	view →
LGG	DFS	Median	All	0.647	0.824	<.001	54	view →
ACC	OS	Tertile	III,IV	0.159	0.878	.001	53	view →
THYM	OS	Tertile	II,III,IV	1.000	0.641	.004	16	view →
SKCM	OS	Quartile	IV	0.686	0.290	.005	16	view →
LUAD	DFS	Tertile	All	0.882	0.747	.006	16	view →
GBM	DFS	Quartile	All	0.185	0.376	.008	15	view →
THCA	DFS	Tertile	II,III,IV	0.618	0.921	.009	15	view →
STAD	DFS	Median	IV	0.134	0.500	.005	12	view →
CHOL	DFS	Median	All	0.606	0.244	.024	12	view →
UCS	OS	Tertile	IV	0.352	1.000	.036	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PRKAR1B-AS1–KIRC (DFS)

Open the KIRC breakdown →