PRKAR1AP1

Across TCGA pan-cancer cohorts, PRKAR1AP1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PRKAR1AP1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PRKAR1AP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRKAR1AP1 expression acts as an unfavorable survival marker, although some lineages such as COAD and KIRP show a favorable association.

KIRC, COAD, and KIRP are the cancer types where PRKAR1AP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	IV	0.165	0.408	.007	76	view →
COAD	DFS	Median	IV	0.657	0.323	<.001	52	view →
KIRP	OS	Median	III,IV	0.743	0.254	<.001	48	view →
UCEC	DFS	Quartile	All	0.858	0.929	.003	40	view →
UCS	OS	Median	II,III,IV	0.734	0.467	.014	38	view →
LUSC	DFS	Tertile	III,IV	0.367	0.647	.003	35	view →
SKCM	DFS	Median	IV	0.195	0.710	.002	24	view →
READ	DFS	Tertile	II,III,IV	0.943	0.409	.007	24	view →
UVM	DFS	Tertile	All	0.259	0.759	.032	18	view →
ESCA	OS	Median	III,IV	0.565	0.312	.010	18	view →
CESC	OS	Tertile	II,III,IV	0.826	0.415	.018	18	view →
DLBC	OS	Quartile	II,III,IV	0.511	0.820	.013	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PRKAR1AP1–KIRC (DFS)

Open the KIRC breakdown →