PRKAR1A

Across TCGA pan-cancer cohorts, PRKAR1A mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PRKAR1A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PRKAR1A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PRKAR1A is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, CCRCC, and LUAD are the cancer types where PRKAR1A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKAR1A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.891	<.001	11	view →
CCRCC	All	II,III,IV	+0.169	<.001	11	view →
LUAD	Female	II,III,IV	−0.259	<.001	9	view →
HNSC	Male	II,III,IV	−0.478	<.001	8	view →
LSCC	Male	All	−0.189	<.001	6	view →
PDAC	All	IV	−0.813	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PRKAR1A–COAD

Open the COAD breakdown →