PRKAG3

Across TCGA patient cohorts, PRKAG3 mutation is significantly associated with the RNA expression of many other genes, with 1,522 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKAG3-associated genes across cancer lineages are SNORA74C-2, BAG3, and SUPV3L1. Each is linked with PRKAG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAG3-to-partner and partner-to-PRKAG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORA74C-2 grouped by PRKAG3-low versus PRKAG3-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAG3→partner) and Y-score (partner→PRKAG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	SNORA74C-2 →	+0.335	+5.039	<.001	.008	3	2
UCEC	BAG3 →	+0.537	+2.000	.002	.003	3	2
UCEC	SUPV3L1 →	+0.444	+2.403	<.001	<.001	3	2
UCEC	PWWP3A →	+0.498	+3.119	<.001	<.001	3	2
UCEC	GAL →	-1.104	-3.875	<.001	<.001	3	2
UCEC	SF3B2 →	+0.339	+2.403	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,522 associations by consensus.

SNORA74C-2 by PRKAG3 expression — READ

Explore this box plot interactively →