PRKAG3

Across TCGA cell cohorts, PRKAG3 RNA expression is significantly associated with the go_rna of many other GO terms, with 742 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PRKAG3-associated GO terms across cancer lineages are Negative regulation of mRNA metabolic process, Regulation of mRNA catabolic process, and Vitamin K metabolic process. Each is linked with PRKAG3 in more than 5 cancer types. Because this analysis shows association rather than direction, both PRKAG3-to-partner and partner-to-PRKAG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA metabolic process grouped by PRKAG3-low versus PRKAG3-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAG3→partner) and Y-score (partner→PRKAG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of mRNA metabolic process →	+0.064	+0.093	<.001	.009	2	6
BREAST	Regulation of mRNA catabolic process →	+0.044	+0.114	<.001	.001	3	5
KIDNEY	Vitamin K metabolic process →	-0.092	-0.019	.005	.001	3	5
LUNG_NSCLC_LUAD	Nucleic acid catabolic process →	+0.037	+0.018	<.001	<.001	3	4
LUNG_NSCLC_LUAD	Regulation of stem cell population maintenance →	+0.032	+0.011	.004	.004	3	4
LUNG_NSCLC_LUAD	Regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.037	+0.013	.002	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 742 associations by consensus.

Negative regulation of mRNA metabolic process by PRKAG3 expression — BREAST

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