PRKAG2

Across TCGA patient cohorts, PRKAG2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,838 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRKAG2-associated genes across cancer lineages are CLIC5, STEAP4, and PDK4. Each is linked with PRKAG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRKAG2-to-partner and partner-to-PRKAG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRKAG2 versus CLIC5 in LSCC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAG2→partner) and Y-score (partner→PRKAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLIC5 →	+0.896	+0.251	<.001	<.001	3	4
LUAD	STEAP4 →	+1.428	+0.263	<.001	<.001	3	4
LSCC	PDK4 →	+1.365	+0.265	<.001	<.001	3	4
HNSC	RHEB →	+0.397	+0.285	.003	.005	3	3
UCEC	KHDC1 →	-0.645	-0.376	.002	.002	3	3
UCEC	ZNF385B →	+1.089	+0.361	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,838 associations by consensus.

PRKAG2 vs CLIC5 — LSCC

Explore this scatter interactively →