PRKAG2

Across TCGA patient cohorts, PRKAG2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKAG2-associated genes across cancer lineages are mTOR_pS2448, Shc_pY317, and Chk2_pT68. Each is linked with PRKAG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAG2-to-partner and partner-to-PRKAG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by PRKAG2-low versus PRKAG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAG2→partner) and Y-score (partner→PRKAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.102	-1.687	.044	.040	3	2
UCEC	Shc_pY317 →	-0.201	-2.807	<.001	.002	3	2
UCEC	Chk2_pT68 →	-0.148	-3.295	.019	.009	3	2
UCEC	cIAP →	+0.105	+1.541	.024	.009	3	2
UCEC	4E-BP1 →	+0.230	+2.614	.012	.005	3	2
UCEC	Di-Ras3 →	-0.195	-3.794	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

mTOR_pS2448 by PRKAG2 expression — UCEC

Explore this box plot interactively →