PRKAG2

Across TCGA cell cohorts, PRKAG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,346 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PRKAG2-associated GO terms across cancer lineages are Positive regulation of gluconeogenesis, Endoplasmic reticulum-plasma membrane tethering, and Positive regulation of focal adhesion assembly. Each is linked with PRKAG2 in more than 12 cancer types. Because this analysis shows association rather than direction, both PRKAG2-to-partner and partner-to-PRKAG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of gluconeogenesis grouped by PRKAG2-low versus PRKAG2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAG2→partner) and Y-score (partner→PRKAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of gluconeogenesis →	+0.147	+1.287	.005	.008	1	13
LIVER	Endoplasmic reticulum-plasma membrane tethering →	+0.272	+1.722	.001	.002	3	10
LIVER	Positive regulation of focal adhesion assembly →	+0.139	+1.636	<.001	.002	3	10
LIVER	Negative regulation of dendritic cell apoptotic process →	+1.984	+1.843	<.001	.001	3	10
BREAST	Lens fiber cell morphogenesis →	+0.189	+0.946	.001	.002	3	9
URINARY_TRACT	Positive regulation of cell-substrate junction organization →	+0.106	+1.310	.004	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,346 associations by consensus.

Positive regulation of gluconeogenesis by PRKAG2 expression — LUNG_NSCLC_LUSC

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