PRKAG2

Across TCGA cell cohorts, PRKAG2 mutation is significantly associated with the RNA expression of many other genes, with 62 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKAG2-associated genes across cancer lineages are OR4F6, GZMK, and IL36A. Each is linked with PRKAG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAG2-to-partner and partner-to-PRKAG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F6 grouped by PRKAG2-low versus PRKAG2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAG2→partner) and Y-score (partner→PRKAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR4F6 →	+0.019	+5.209	<.001	.005	3	1
BREAST	GZMK →	+0.063	+5.169	<.001	.005	3	1
BREAST	IL36A →	+0.085	+5.169	<.001	.005	3	1
BREAST	MT1B →	+0.113	+5.169	<.001	.005	3	1
BREAST	OR2G6 →	+0.016	+5.169	<.001	.005	3	1
LARGE_INTESTINE	EIF3L →	+0.477	+3.067	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

OR4F6 by PRKAG2 expression — BLOOD_Lymphoma

Explore this box plot interactively →