PRKAG1

Across TCGA pan-cancer cohorts, PRKAG1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PRKAG1 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PRKAG1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PRKAG1 expression acts as an unfavorable survival marker.

KIRP, LUAD, and KICH are the cancer types where PRKAG1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.178	0.885	<.001	18	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	15	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LGG	DFS	Median	All	0.249	0.738	.027	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PRKAG1–KIRP (OS)

Open the KIRP breakdown →