PRKAG1

Across TCGA pan-cancer cohorts, PRKAG1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PRKAG1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PRKAG1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PRKAG1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where PRKAG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.928	0.105	.006	25	view →
LUAD	DFS	Quartile	All	0.392	0.842	.001	23	view →
PDAC	OS	Quartile	III,IV	0.763	0.159	.006	10	view →
HNSC	DFS	Tertile	III,IV	1.000	0.911	.036	3	view →
GBM	OS	Median	All	0.664	0.861	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PRKAG1–CCRCC (DFS)

Open the CCRCC breakdown →