PRKAG1

Across TCGA patient cohorts, PRKAG1 mutation is significantly associated with the RNA expression of many other genes, with 2,457 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKAG1-associated genes across cancer lineages are MIR8062, ITGB1, and SEC24D. Each is linked with PRKAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAG1-to-partner and partner-to-PRKAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8062 grouped by PRKAG1-low versus PRKAG1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAG1→partner) and Y-score (partner→PRKAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR8062 →	+0.592	+8.471	<.001	.005	3	2
UCEC	ITGB1 →	+0.679	+1.673	.006	.007	3	2
UCEC	SEC24D →	+0.722	+2.010	<.001	.001	3	2
UCEC	SAR1B →	+0.554	+2.392	<.001	<.001	3	2
UCEC	CCSAP →	+0.656	+2.815	<.001	.001	3	2
UCEC	MORC3 →	+0.398	+2.010	.009	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,457 associations by consensus.

MIR8062 by PRKAG1 expression — BRCA

Explore this box plot interactively →