PRKAG1

Across TCGA patient cohorts, PRKAG1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKAG1-associated genes across cancer lineages are JNK2, eIF4G, and ERK2. Each is linked with PRKAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAG1-to-partner and partner-to-PRKAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PRKAG1-low versus PRKAG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAG1→partner) and Y-score (partner→PRKAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.265	+1.884	<.001	.030	3	2
UCEC	eIF4G →	+0.254	+2.321	.037	.033	3	1
UCEC	ERK2 →	+0.184	+2.321	.015	.034	3	1
UCEC	MEK1 →	+0.526	+3.169	<.001	<.001	3	1
UCEC	p62 Lck ligand →	+0.275	+3.169	.031	.018	3	1
UCEC	PCNA →	+0.246	+2.459	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

JNK2 by PRKAG1 expression — UCEC

Explore this box plot interactively →