PRKACB

Across TCGA pan-cancer cohorts, PRKACB mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PRKACB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PRKACB mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PRKACB is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

COAD, PDAC, and LUAD are the cancer types where PRKACB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKACB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−1.042	<.001	12	view →
PDAC	All	III,IV	−0.527	<.001	9	view →
LUAD	Female	II,III,IV	−0.436	<.001	9	view →
LSCC	Male	II,III,IV	−0.444	<.001	8	view →
CCRCC	Male	IV	−0.340	<.001	8	view →
HNSC	All	II,III,IV	−0.167	.003	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PRKACB–COAD

Open the COAD breakdown →