PRKACA

Across TCGA pan-cancer cohorts, PRKACA mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PRKACA’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PRKACA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PRKACA is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, LSCC, and HNSC are the cancer types where PRKACA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKACA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.456	<.001	10	view →
LSCC	Female	II,III,IV	−0.513	<.001	9	view →
HNSC	All	II,III,IV	−0.444	<.001	8	view →
CCRCC	Male	III,IV	−0.369	<.001	8	view →
PDAC	All	All	−0.201	.004	5	view →
LUAD	Male	II,III,IV	−0.152	<.001	5	view →
OV	All	All	−0.371	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PRKACA–COAD

Open the COAD breakdown →