PRKACA

Across TCGA patient cohorts, PRKACA RNA expression is significantly associated with the protein abundance of many other proteins, with 10,317 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PRKACA-associated proteins across cancer lineages are HTT_S640, NUCKS1_S144, and WASHC2A_S539. Each is linked with PRKACA in more than 4 cancer types. Because this analysis shows association rather than direction, both PRKACA-to-partner and partner-to-PRKACA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRKACA versus HTT_S640 in LUAD, with a Pearson correlation of -0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKACA→partner) and Y-score (partner→PRKACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HTT_S640 →	-0.735	-0.409	<.001	<.001	3	5
GBM	NUCKS1_S144 →	+0.940	+0.324	<.001	.006	3	4
HNSC	WASHC2A_S539 →	-0.791	-1.045	<.001	<.001	3	4
LSCC	MAST2_S92 →	-0.519	-0.487	<.001	<.001	3	4
LUAD	ZZEF1_S1464 →	-0.629	-0.450	.002	<.001	3	3
OV	TBC1D10B_S633 →	+1.740	+1.253	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,317 associations by consensus.

PRKACA vs HTT_S640 — LUAD

Explore this scatter interactively →