PRKACA

Across TCGA patient cohorts, PRKACA protein abundance is significantly associated with the RNA expression of many other genes, with 19,229 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PRKACA-associated genes across cancer lineages are SH3BP5, ZNF136, and ZNF627. Each is linked with PRKACA in more than 3 cancer types. Because this analysis shows association rather than direction, both PRKACA-to-partner and partner-to-PRKACA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRKACA versus SH3BP5 in HNSC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKACA→partner) and Y-score (partner→PRKACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SH3BP5 →	+0.746	+0.485	<.001	<.001	3	4
HNSC	ZNF136 →	+0.558	+0.420	<.001	<.001	3	4
OV	ZNF627 →	+0.767	+0.426	.001	<.001	3	4
LUAD	CLECL1 →	+0.794	+0.270	<.001	<.001	3	4
LUAD	KCNIP1-OT1 →	+0.465	+0.192	<.001	<.001	3	4
LSCC	NFATC2 →	+0.630	+0.185	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,229 associations by consensus.

PRKACA vs SH3BP5 — HNSC

Explore this scatter interactively →