PRKACA

Across TCGA patient cohorts, PRKACA mutation is significantly associated with the RNA expression of many other genes, with 2,133 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKACA-associated genes across cancer lineages are KIAA1143P2, ARF1P1, and ARL5AP1. Each is linked with PRKACA in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKACA-to-partner and partner-to-PRKACA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIAA1143P2 grouped by PRKACA-low versus PRKACA-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKACA→partner) and Y-score (partner→PRKACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	KIAA1143P2 →	+0.133	+4.812	<.001	.006	3	2
SKCM	ARF1P1 →	+0.081	+3.906	<.001	.001	3	2
SKCM	ARL5AP1 →	+0.050	+4.475	<.001	.005	3	2
SKCM	LLPHP1 →	+0.129	+3.564	<.001	.005	3	2
CESC	RN7SL62P →	+0.110	+4.812	<.001	.006	3	2
UCEC	SMIM28 →	+0.319	+1.700	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,133 associations by consensus.

KIAA1143P2 by PRKACA expression — CESC

Explore this box plot interactively →