PRKACA

Across TCGA patient cohorts, PRKACA mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKACA-associated genes across cancer lineages are Caspase-8, EGFR_pY1068, and eIF4E. Each is linked with PRKACA in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKACA-to-partner and partner-to-PRKACA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by PRKACA-low versus PRKACA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKACA→partner) and Y-score (partner→PRKACA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.231	-2.673	.014	.005	3	2
UCEC	EGFR_pY1068 →	-0.208	-2.459	.027	.018	3	1
UCEC	eIF4E →	+0.220	+2.169	.005	.003	3	1
UCEC	eIF4G →	+0.305	+3.459	.008	.005	3	1
UCEC	FoxM1 →	+0.294	+2.169	.002	.003	3	1
UCEC	GAPDH →	+0.487	+3.584	.015	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Caspase-8 by PRKACA expression — UCEC

Explore this box plot interactively →